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Simvastatin Reduces Burn Injury-induced Splenic Apoptosis via Down-regulation of the TNF-α/ NF-κB Pathway

OBJECTIVE: Recent studies have suggested that epidermal burn injuries are associated with inflammation and immune dysfunction. Simvastatin has been shown to possess potent anti-inflammatory properties. Thus we hypothesized that simvastatin protects against burn-induced apoptosis in spleen via its an...

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Bibliografische gegevens
Gepubliceerd in:Ann Surg
Hoofdauteurs: Zhao, Gaofeng, Yu, Yong-Ming, Kaneki, Masao, Bonab, Ali A., Tompkins, Ronald G., Fischman, Alan J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272342/
https://ncbi.nlm.nih.gov/pubmed/24950285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SLA.0000000000000764
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