Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation

Effects of concurrent inhibition of mTORC1/2 and Bcl-2/Bcl-xL in human acute myeloid leukemia cells were examined. Tetracycline-inducible Bcl-2/Bcl-xL dual knockdown markedly sensitized acute myeloid leukemia cells to the dual TORC1/2 inhibitor INK128 in vitro as well as in vivo. Moreover, INK128 co...

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Publicat a:Haematologica
Autors principals: Rahmani, Mohamed, Aust, Mandy Mayo, Hawkins, Elisa, Parker, Rebecca E., Ross, Masey, Kmieciak, Maciej, Reshko, Leonid Borisovich, Rizzo, Kathryn A., Dumur, Catherine I., Ferreira-Gonzalez, Andrea, Grant, Steven
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666331/
https://ncbi.nlm.nih.gov/pubmed/26452980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.130351
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