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Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions

The Biopharmaceutics Drug Disposition Classification System (BDDCS) can be utilized to predict drug disposition, including interactions with other drugs and transporter or metabolizing enzyme effects based on the extent of metabolism and solubility of a drug. However, defining the extent of metaboli...

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Bibliographic Details
Published in:Mol Pharm
Main Authors: Hosey, Chelsea M, Benet, Leslie Z
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666302/
https://ncbi.nlm.nih.gov/pubmed/25816851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500783g
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