Physical and functional interaction between WT1 and p53 proteins.

WT1 is a tumor-suppressor gene expressed in the developing kidney, whose inactivation leads to the development of Wilms tumor, a pediatric kidney cancer. WT1 encodes a transcription factor which binds to the EGR1 consensus sequence, mediating transcriptional repression. We now demonstrate that p53,...

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Auteurs principaux: Maheswaran, S, Park, S, Bernard, A, Morris, J F, Rauscher, F J, Hill, D E, Haber, D A
Format: Artigo
Langue:Inglês
Publié: 1993
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC46662/
https://ncbi.nlm.nih.gov/pubmed/8389468
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