Dmp1 physically interacts with p53 and positively regulates p53’s stability, nuclear localization, and function

The transcription factor Dmp1 is a Ras/HER2-activated haplo-insufficient tumor suppressor that activates the Arf/p53 pathway of cell cycle arrest. Recent evidence suggests that Dmp1 may activate p53 independently of Arf in certain cell types. Here we report findings supporting this concept with the...

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Main Authors: Frazier, Donna P., Kendig, Robert D., Kai, Fumitake, Maglic, Dejan, Sugiyama, Takayuki, Morgan, Rachel L., Fry, Elizabeth A., Lagedrost, Sarah J., Sui, Guangchao, Inoue, Kazushi
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319807/
https://ncbi.nlm.nih.gov/pubmed/22331460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2410
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