Intra-tumor heterogeneity in TP53 null High Grade Serous Ovarian Carcinoma progression

BACKGROUND: High grade serous ovarian cancer is characterised by high initial response to chemotherapy but poor outcome in the long term due to acquired resistance. One of the main genetic features of this disease is TP53 mutation. The majority of TP53 mutated tumors harbor missense mutations in thi...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Mota, Alba, Triviño, Juan Carlos, Rojo-Sebastian, Alejandro, Martínez-Ramírez, Ángel, Chiva, Luis, González-Martín, Antonio, Garcia, Juan F., Garcia-Sanz, Pablo, Moreno-Bueno, Gema
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666042/
https://ncbi.nlm.nih.gov/pubmed/26620706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1952-z
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