Motif mimetic of epsin perturbs tumor growth and metastasis

Tumor angiogenesis is critical for cancer progression. In multiple murine models, endothelium-specific epsin deficiency abrogates tumor progression by shifting the balance of VEGFR2 signaling toward uncontrolled tumor angiogenesis, resulting in dysfunctional tumor vasculature. Here, we designed a tu...

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Publicat a:J Clin Invest
Autors principals: Dong, Yunzhou, Wu, Hao, Rahman, H.N. Ashiqur, Liu, Yanjun, Pasula, Satish, Tessneer, Kandice L., Cai, Xiaofeng, Liu, Xiaolei, Chang, Baojun, McManus, John, Hahn, Scott, Dong, Jiali, Brophy, Megan L., Yu, Lili, Song, Kai, Silasi-Mansat, Robert, Saunders, Debra, Njoku, Charity, Song, Hoogeun, Mehta-D’Souza, Padmaja, Towner, Rheal, Lupu, Florea, McEver, Rodger P., Xia, Lijun, Boerboom, Derek, Srinivasan, R. Sathish, Chen, Hong
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665789/
https://ncbi.nlm.nih.gov/pubmed/26571402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80349
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