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Therapeutic efficacy of a synthetic epsin mimetic peptide in glioma tumor model: uncovering multiple mechanisms beyond the VEGF-associated tumor angiogenesis

Binding of epsin ubiquitin-interacting motif (UIM) with ubiquitylated VEGFR2 is a critical mechanism for epsin-dependent VEGFR2 endocytosis and physiological angiogenesis. Deletion of epsins in vessel endothelium produces uncontrolled tumor angiogenesis and retards tumor growth in animal models. The...

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書誌詳細
出版年:J Neurooncol
主要な著者: Dong, Jerry, Saunders, Debra, Silasi-Mansat, Robert, Yu, Lili, Zhu, Hua, Lupu, Florea, Towner, Rheal, Dong, Yunzhou, Chen, Hong
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930063/
https://ncbi.nlm.nih.gov/pubmed/29357089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-018-2766-z
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