Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling

Epsins are a family of ubiquitin-binding, endocytic clathrin adaptors. Mice lacking both epsins 1 and 2 (Epn1/2) die at embryonic day 10 and exhibit an abnormal vascular phenotype. To examine the angiogenic role of endothelial epsins, we generated mice with constitutive or inducible deletion of Epn1...

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Detalhes bibliográficos
Main Authors: Pasula, Satish, Cai, Xiaofeng, Dong, Yunzhou, Messa, Mirko, McManus, John, Chang, Baojun, Liu, Xiaolei, Zhu, Hua, Mansat, Robert Silasi, Yoon, Seon-Joo, Hahn, Scott, Keeling, Jacob, Saunders, Debra, Ko, Genevieve, Knight, John, Newton, Gail, Luscinskas, Francis, Sun, Xiaohong, Towner, Rheal, Lupu, Florea, Xia, Lijun, Cremona, Ottavio, De Camilli, Pietro, Min, Wang, Chen, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533553/
https://ncbi.nlm.nih.gov/pubmed/23187125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64537
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