Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer

Mutations in genes encoding chromatin-remodeling proteins are often identified in a variety of cancers. For example, the histone demethylase JARID1C is frequently inactivated in patients with clear cell renal cell carcinoma (ccRCC); however, it is largely unknown how JARID1C dysfunction promotes can...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Rondinelli, Beatrice, Rosano, Dalia, Antonini, Elena, Frenquelli, Michela, Montanini, Laura, Huang, DaChuan, Segalla, Simona, Yoshihara, Kosuke, Amin, Samir B., Lazarevic, Dejan, The, Bin Tean, Verhaak, Roel G.W., Futreal, P. Andrew, Di Croce, Luciano, Chin, Lynda, Cittaro, Davide, Tonon, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665784/
https://ncbi.nlm.nih.gov/pubmed/26551685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81040
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