Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors

The incidence of cancer is higher in the elderly; however, many of the underlying mechanisms for this association remain unexplored. Here, we have shown that B cell progenitors in old mice exhibit marked signaling, gene expression, and metabolic defects. Moreover, B cell progenitors that developed f...

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Vydáno v:J Clin Invest
Hlavní autoři: Henry, Curtis J., Casás-Selves, Matias, Kim, Jihye, Zaberezhnyy, Vadym, Aghili, Leila, Daniel, Ashley E., Jimenez, Linda, Azam, Tania, McNamee, Eoin N., Clambey, Eric T., Klawitter, Jelena, Serkova, Natalie J., Tan, Aik Choon, Dinarello, Charles A., DeGregori, James
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665776/
https://ncbi.nlm.nih.gov/pubmed/26551682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83024
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