Coordinate expression of heme and globin is essential for effective erythropoiesis

Erythropoiesis requires rapid and extensive hemoglobin production. Heme activates globin transcription and translation; therefore, heme synthesis must precede globin synthesis. As free heme is a potent inducer of oxidative damage, its levels within cellular compartments require stringent regulation....

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Foilsithe in:J Clin Invest
Main Authors: Doty, Raymond T., Phelps, Susan R., Shadle, Christina, Sanchez-Bonilla, Marilyn, Keel, Siobán B., Abkowitz, Janis L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665774/
https://ncbi.nlm.nih.gov/pubmed/26551679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83054
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