A strategy for combating melanoma with oncogenic c-Myc inhibitors and targeted nanotherapy

AIMS: The activity of the transcription factor c-Myc is dependent upon heterodimerization with Max to control target gene transcription. Small-molecule inhibitors of c-Myc–Max have exhibited low potency and poor water solubility and are therefore unsuitable for in vivo application. We hypothesized t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nanomedicine (Lond)
Prif Awduron: Pan, Dipanjan, Kim, Benjamin, Hu, Grace, Gupta, Deepti Sood, Senpan, Angana, Yang, Xiaoxia, Schmieder, Anne, Swain, Corban, Wickline, Samuel A, Tomasson, Michael H, Lanza, Gregory M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665613/
https://ncbi.nlm.nih.gov/pubmed/25600969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.14.101
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