Small Molecule MYC Inhibitor Conjugated to Integrin-Targeted Nanoparticles Extends Survival in a Mouse Model of Disseminated Multiple Myeloma

Multiple myeloma pathogenesis is driven by the MYC oncoprotein, its dimerization with MAX, and the binding of this heterodimer to E-Boxes in the vicinity of target genes. The systemic utility of potent small molecule inhibitors of MYC-MAX dimerization was limited by poor bioavailability, rapid metab...

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Udgivet i:Mol Cancer Ther
Main Authors: Soodgupta, Deepti, Pan, Dipanjan, Cui, Grace, Senpan, Angana, Yang, Xiaoxia, Lu, Lan, Weilbaecher, Katherine N., Prochownik, Edward V., Lanza, Gregory M., Tomasson, Michael H.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571491/
https://ncbi.nlm.nih.gov/pubmed/25824336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0774-T
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