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Genetic Pathway of HIV-1 Resistance to Novel Fusion Inhibitors Targeting the Gp41 Pocket

The peptide drug enfuvirtide (T20) is the only HIV-1 fusion inhibitor in clinical use, but it easily induces drug resistance, calling for new strategies for developing effective drugs. On the basis of the M-T hook structure, we recently developed highly potent short-peptide HIV-1 fusion inhibitors (...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Su, Yang, Chong, Huihiui, Xiong, Shengwen, Qiao, Yuanyuan, Qiu, Zonglin, He, Yuxian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665254/
https://ncbi.nlm.nih.gov/pubmed/26446597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01741-15
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