Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket

The deep hydrophobic pocket of HIV-1 gp41 has been considered a drug target, but short-peptides targeting this site usually lack potent antiviral activity. By applying the M-T hook structure, we previously generated highly potent short-peptide fusion inhibitors that specifically targeted the pocket...

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Vydáno v:Front Cell Infect Microbiol
Hlavní autoři: Zhang, Xiujuan, Zhu, Yuanmei, Hu, Hao, Zhang, Senyan, Wang, Pengfei, Chong, Huihui, He, Jinsheng, Wang, Xinquan, He, Yuxian
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834435/
https://ncbi.nlm.nih.gov/pubmed/29535974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00051
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