Hydrodynamic Gene Delivery of CC Chemokine Binding Fc Fusion Proteins to Target Acute Vascular Inflammation In Vivo

Blockade of CC chemokines is an attractive yet under utilized therapeutic strategy. We report the in vivo pharmacokinetics of a broad-spectrum vaccinia virus CC chemokine binding protein (35 K) fused to human IgG1 Fc. We demonstrate that the in vivo efficacy of the protein can be interrogated using...

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Veröffentlicht in:Sci Rep
Hauptverfasser: McNeill, Eileen, Iqbal, Asif J., White, Gemma E., Patel, Jyoti, Greaves, David R., Channon, Keith M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664965/
https://ncbi.nlm.nih.gov/pubmed/26620767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17404
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