RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function

RBFOX3 mutations are linked to epilepsy and cognitive impairments, but the underlying pathophysiology of these disorders is poorly understood. Here we report replication of human symptoms in a mouse model with disrupted Rbfox3. Rbfox3 knockout mice displayed increased seizure susceptibility and decr...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Wang, Han-Ying, Hsieh, Pei-Fen, Huang, De-Fong, Chin, Pey-Shyuan, Chou, Chih-Hsuan, Tung, Chun-Che, Chen, Shin-Yuan, Lee, Li-Jen, Gau, Susan Shur-Fen, Huang, Hsien-Sung
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664964/
https://ncbi.nlm.nih.gov/pubmed/26619789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17383
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