RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function

RBFOX3 mutations are linked to epilepsy and cognitive impairments, but the underlying pathophysiology of these disorders is poorly understood. Here we report replication of human symptoms in a mouse model with disrupted Rbfox3. Rbfox3 knockout mice displayed increased seizure susceptibility and decr...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Wang, Han-Ying, Hsieh, Pei-Fen, Huang, De-Fong, Chin, Pey-Shyuan, Chou, Chih-Hsuan, Tung, Chun-Che, Chen, Shin-Yuan, Lee, Li-Jen, Gau, Susan Shur-Fen, Huang, Hsien-Sung
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664964/
https://ncbi.nlm.nih.gov/pubmed/26619789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17383
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky