RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function

RBFOX3 mutations are linked to epilepsy and cognitive impairments, but the underlying pathophysiology of these disorders is poorly understood. Here we report replication of human symptoms in a mouse model with disrupted Rbfox3. Rbfox3 knockout mice displayed increased seizure susceptibility and decr...

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Publicat a:Sci Rep
Autors principals: Wang, Han-Ying, Hsieh, Pei-Fen, Huang, De-Fong, Chin, Pey-Shyuan, Chou, Chih-Hsuan, Tung, Chun-Che, Chen, Shin-Yuan, Lee, Li-Jen, Gau, Susan Shur-Fen, Huang, Hsien-Sung
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664964/
https://ncbi.nlm.nih.gov/pubmed/26619789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17383
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