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Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow

The NMDA receptor (R) plays important roles in brain physiology and pathology as an ion channel. Here we examine the ion flow-independent coupling of agonist to the NMDAR cytoplasmic domain (cd). We measure FRET between fluorescently tagged cytoplasmic domains of GluN1 subunits of NMDARs expressed i...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dore, Kim, Aow, Jonathan, Malinow, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664357/
https://ncbi.nlm.nih.gov/pubmed/26553997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520023112
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