Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V

Myosins use a conserved structural mechanism to convert the energy from ATP hydrolysis into a large swing of the force-generating lever arm. The precise timing of the lever arm movement with respect to the steps in the actomyosin ATPase cycle has not been determined. We have developed a FRET system...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Trivedi, Darshan V., Muretta, Joseph M., Swenson, Anja M., Davis, Jonathon P., Thomas, David D., Yengo, Christopher M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664342/
https://ncbi.nlm.nih.gov/pubmed/26553992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517566112
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