Dynamic allostery governs cyclophilin A–HIV capsid interplay

Host factor protein Cyclophilin A (CypA) regulates HIV-1 viral infectivity through direct interactions with the viral capsid, by an unknown mechanism. CypA can either promote or inhibit viral infection, depending on host cell type and HIV-1 capsid (CA) protein sequence. We have examined the role of...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Lu, Manman, Hou, Guangjin, Zhang, Huilan, Suiter, Christopher L., Ahn, Jinwoo, Byeon, In-Ja L., Perilla, Juan R., Langmead, Christopher J., Hung, Ivan, Gor'kov, Peter L., Gan, Zhehong, Brey, William, Aiken, Christopher, Zhang, Peijun, Schulten, Klaus, Gronenborn, Angela M., Polenova, Tatyana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664340/
https://ncbi.nlm.nih.gov/pubmed/26553990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516920112
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