Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions

Results from genome-wide association studies (GWAS) have indicated that strong single-gene effects are the exception, not the rule, for most diseases. We assessed the joint effects of germline genetic variations through a pathway-based approach that considers the tissue-specific contexts of GWAS fin...

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I publikationen:Hum Mol Genet
Huvudupphovsmän: Qian, David C., Byun, Jinyoung, Han, Younghun, Greene, Casey S., Field, John K., Hung, Rayjean J., Brhane, Yonathan, Mclaughlin, John R., Fehringer, Gordon, Landi, Maria Teresa, Rosenberger, Albert, Bickeböller, Heike, Malhotra, Jyoti, Risch, Angela, Heinrich, Joachim, Hunter, David J., Henderson, Brian E., Haiman, Christopher A., Schumacher, Fredrick R., Eeles, Rosalind A., Easton, Douglas F., Seminara, Daniela, Amos, Christopher I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2015
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664175/
https://ncbi.nlm.nih.gov/pubmed/26483192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv440
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