Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase

Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset disease characterized by upper and lower motor neuron degeneration, muscle wasting and paralysis. Growing evidence suggests a link between changes in lipid metabolism and ALS. Here, we used UPLC/TOF-MS to survey the lipidome in SOD1(G86R) mi...

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Publicat a:Hum Mol Genet
Autors principals: Henriques, Alexandre, Croixmarie, Vincent, Priestman, David A., Rosenbohm, Angela, Dirrig-Grosch, Sylvie, D'Ambra, Eleonora, Huebecker, Mylene, Hussain, Ghulam, Boursier-Neyret, Claire, Echaniz-Laguna, Andoni, Ludolph, Albert C., Platt, Frances M., Walther, Bernard, Spedding, Michael, Loeffler, Jean-Philippe, Gonzalez De Aguilar, Jose-Luis
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664174/
https://ncbi.nlm.nih.gov/pubmed/26483191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv439
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