Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing

Mitochondrial dysfunction is a well-established cause of sensorineural deafness, but the pathophysiological events are poorly understood. Non-syndromic deafness and predisposition to aminoglycoside-induced deafness can be caused by specific mutations in the 12S rRNA gene of mtDNA and are thus matern...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Lee, Seungmin, Rose, Simon, Metodiev, Metodi D., Becker, Lore, Vernaleken, Alexandra, Klopstock, Thomas, Gailus-Durner, Valerie, Fuchs, Helmut, Hrabě De Angelis, Martin, Douthwaite, Stephen, Larsson, Nils-Göran
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664167/
https://ncbi.nlm.nih.gov/pubmed/26464487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv427
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