NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly

Biogenesis of mammalian mitochondrial ribosomes requires a concerted maturation of both the small (SSU) and large subunit (LSU). We demonstrate here that the m(5)C methyltransferase NSUN4, which forms a complex with MTERF4, is essential in mitochondrial ribosomal biogenesis as mitochondrial translat...

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Autors principals: Metodiev, Metodi Dimitrov, Spåhr, Henrik, Loguercio Polosa, Paola, Meharg, Caroline, Becker, Christian, Altmueller, Janine, Habermann, Bianca, Larsson, Nils-Göran, Ruzzenente, Benedetta
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916286/
https://ncbi.nlm.nih.gov/pubmed/24516400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004110
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