IGF2BP2/IMP2 Deficient Mice Resist Obesity through enhanced translation of Ucp1 mRNA and other mRNAs encoding Mitochondrial Proteins

Although variants in the IGF2BP2/IMP2 gene confer risk for Type 2 diabetes, IMP2, an RNA binding protein, is not known to regulate metabolism. Imp2(−/−) mice gain less lean mass after weaning and have increased lifespan. Imp2(−/−) mice are highly resistant to diet-induced obesity and fatty liver and...

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Udgivet i:Cell Metab
Main Authors: Dai, Ning, Zhao, Liping, Wrighting, Diedra, Krämer, Dana, Majithia, Amit, Wang, Yanqun, Cracan, Valentin, Borges-Rivera, Diego, Mootha, Vamsi K., Nahrendorf, Matthias, Thorburn, David R., Minichiello, Liliana, Altshuler, David, Avruch, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663978/
https://ncbi.nlm.nih.gov/pubmed/25863250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.03.006
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