mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

Variants in the IMP2 (insulin-like growth factor 2 [IGF2] mRNA-binding protein 2) gene are implicated in susceptibility to type 2 diabetes. We describe the ability of mammalian target of rapamycin (mTOR) to regulate the cap-independent translation of IGF2 mRNA through phosphorylation of IMP2, an onc...

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Hauptverfasser: Dai, Ning, Rapley, Joseph, Angel, Matthew, Yanik, M. Fatih, Blower, Michael D., Avruch, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2011
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110954/
https://ncbi.nlm.nih.gov/pubmed/21576258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2042311
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