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mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry
Variants in the IMP2 (insulin-like growth factor 2 [IGF2] mRNA-binding protein 2) gene are implicated in susceptibility to type 2 diabetes. We describe the ability of mammalian target of rapamycin (mTOR) to regulate the cap-independent translation of IGF2 mRNA through phosphorylation of IMP2, an onc...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3110954/ https://ncbi.nlm.nih.gov/pubmed/21576258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2042311 |
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