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Chemical conjugation of 2-hexadecynoic acid to C5-Curcumin enhances its antibacterial activity against multi-drug resistant bacteria

The first total synthesis of a C5-Curcumin-2-Hexadecynoic Acid (C5-Curc-2-HDA, 6) conjugate was successfully performed. Through a three-step synthetic route, conjugate 6 was obtained in 13 % overall yield and tested for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA...

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Bibliografiska uppgifter
I publikationen:Bioorg Med Chem Lett
Huvudupphovsmän: Sanabria-Ríos, David J., Rivera-Torres, Yaritza, Rosario, Joshua, Gutierrez, Ricardo, Torres-García, Yeireliz, Montano, Nashbly, Ortíz-Soto, Gabriela, Ríos-Olivares, Eddy, Rodríguez, José W., Carballeira, Néstor M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663078/
https://ncbi.nlm.nih.gov/pubmed/26483137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.022
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