Synthesis of novel C5-curcuminoid-fatty acid conjugates and mechanistic investigation of their anticancer activity

The first synthesis of C5-Curcumin-Fatty Acid (C5-Curc-FA) conjugates was successfully performed. Through a two-step synthetic route, 10 analogs were synthesized for a structure-activity relationship (SAR) study. It was found that C5-Curc-FA conjugates containing either decanoic acid or palmitic aci...

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Udgivet i:Bioorg Med Chem Lett
Main Authors: Sanabria-Ríos, David J., Rivera-Torres, Yaritza, Rosario, Joshua, Ríos, Camille, Gutierrez, Ricardo, Carballeira, Néstor M., Vélez, Christian, Zayas, Beatriz, Álvarez-Cólon, Félix, Ortiz-Soto, Gabriela, Serrano, Victor, Altieri-Rivera, Joanne, Ríos-Olivares, Eddy, Rodríguez, José W.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446575/
https://ncbi.nlm.nih.gov/pubmed/25881826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.03.065
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