Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials

BACKGROUND: Biphasic immediate-release (IR)/extended-release (ER) hydrocodone bitartrate (HB)/acetaminophen (APAP) 7.5/325-mg tablets are formulated with gastroretentive ER drug delivery technology that has been associated with clinically meaningful food effects in other approved products. Two phase...

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Vydáno v:BMC Pharmacol Toxicol
Hlavní autoři: Devarakonda, Krishna, Kostenbader, Kenneth, Giuliani, Michael J., Young, Jim L.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662814/
https://ncbi.nlm.nih.gov/pubmed/26614499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-015-0032-y
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