Single- and multiple-dose pharmacokinetics of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) compared with immediate-release hydrocodone bitartrate/ibuprofen and immediate-release tramadol HCl/acetaminophen

OBJECTIVE: To characterize the single-dose and steady-state pharmacokinetics (PK) of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (IR/ER HB/APAP), IR HB/ibuprofen, and IR tramadol HCl/APAP. METHODS: In this single-center, open-label, randomized, four-period crosso...

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Опубликовано в: :J Pain Res
Главные авторы: Devarakonda, Krishna, Kostenbader, Kenneth, Giuliani, Michael J, Young, Jim L
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2015
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598211/
https://ncbi.nlm.nih.gov/pubmed/26508885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S83416
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