Pharmacokinetics and bioavailability of oxycodone and acetaminophen following single-dose administration of MNK-795, a dual-layer biphasic IR/ER combination formulation, under fed and fasted conditions

BACKGROUND: XARTEMIS™ XR (formerly MNK-795) is a combination oxycodone (OC) and acetaminophen (APAP) analgesic with both immediate-release and extended-release (ER) components (ER OC/APAP). The tablets are designed with gastric-retentive ER oral delivery technology that releases the ER component at...

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Detalhes bibliográficos
Main Authors: Devarakonda, Krishna, Morton, Terri, Margulis, Rachel, Giuliani, Michael, Barrett, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145823/
https://ncbi.nlm.nih.gov/pubmed/25170252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S64261
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