Prolyl isomerase Pin1 regulates axon guidance by stabilizing CRMP2A selectively in distal axons

Axon guidance relies on precise translation of the gradients of the extracellular signals into local changes of cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent responses of growth cones are still poorly understood. Here we show that during embryonic development in growi...

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Udgivet i:Cell Rep
Main Authors: Balastik, Martin, Zhou, Xiao Zhen, Alberich-Jorda, Meritxell, Weissova, Romana, Žiak, Jakub, Pazyra-Murphy, Maria F., Cosker, Katharina E, Machonova, Olga, Kozmikova, Iryna, Chen, Chun-Hau, Pastorino, Lucia, Asara, John M., Cole, Adam, Sutherland, Calum, Segal, Rosalind A., Lu, Kun Ping
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662601/
https://ncbi.nlm.nih.gov/pubmed/26489457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.026
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