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pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity
The peptide-exchange catalyst, HLA-DM, and its inhibitor, HLA-DO control endosomal generation of peptide/class II major histocompatibility protein (MHC-II) complexes; these complexes traffic to the cell surface for inspection by CD4+ T cells. Some evidence suggests that pH influences DO regulation o...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4661524/ https://ncbi.nlm.nih.gov/pubmed/26610428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17333 |
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