TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression

Retinoid-related orphan nuclear receptor γt (RORγt) is a key transcription factor for the development and function of Th17 cells. In this study, we show that tumor necrosis factor receptor-associated factor 5 (TRAF5), known as an E3 ubiquitin protein ligase and signal transducer, interacts with and...

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Vydáno v:J Biol Chem
Hlavní autoři: Wang, Xiuwen, Yang, Jing, Han, Lei, Zhao, Kaixia, Wu, Qingsi, Bao, Liming, Li, Zhiyuan, Lv, Ling, Li, Bin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661420/
https://ncbi.nlm.nih.gov/pubmed/26453305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.664573
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