The E3 Deubiquitinase USP17 Is a Positive Regulator of Retinoic Acid-related Orphan Nuclear Receptor γt (RORγt) in Th17 Cells

Stable retinoic acid-related orphan nuclear receptor γt (RORγt) expression is pivotal for the development and function of Th17 cells. Here we demonstrate that expression of the transcription factor RORγt can be regulated through deubiquitination, which prevents proteasome-mediated degradation. We es...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Han, Lei, Yang, Jing, Wang, Xiuwen, Wu, Qingsi, Yin, Shuying, Li, Zhiyuan, Zhang, Jing, Xing, Yue, Chen, Zuojia, Tsun, Andy, Li, Dan, Piccioni, Miranda, Zhang, Yu, Guo, Qiang, Jiang, Lindi, Bao, Liming, Lv, Ling, Li, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162160/
https://ncbi.nlm.nih.gov/pubmed/25070893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565291
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados