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The Hydrophobic Effect Contributes to the Closed State of a Simplified Ion Channel through a Conserved Hydrophobic Patch at the Pore-Helix Crossing

Ion selectivity-filter structures are strikingly similar throughout the large family of K(++) channels and other p-loop-like receptors (i.e., glutamate receptors). At the same time, the triggers for opening these channels, or gating, are diverse. Two questions that remain unanswered regarding these...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Yonkunas, Michael, Kurnikova, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661268/
https://ncbi.nlm.nih.gov/pubmed/26640439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00284
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