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A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
Piezo1 and Piezo2 belong to a family of mechanically-activated ion channels implicated in a wide range of physiological processes. Mechanical stimulation triggers Piezo channels to open, but their characteristic fast inactivation process results in rapid closure. Several disease-causing mutations in...
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| Pubblicato in: | eLife |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6349400/ https://ncbi.nlm.nih.gov/pubmed/30628892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44003 |
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