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Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening
Arterial stiffening is a hallmark of aging and risk factor for cardiovascular disease, yet its regulation is poorly understood. Here we use mouse modeling to show that matrix metalloproteinase-12 (MMP12), a potent elastase, is essential for acute and chronic arterial stiffening. MMP12 was induced in...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4660439/ https://ncbi.nlm.nih.gov/pubmed/26608672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17189 |
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