Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening

Arterial stiffening is a hallmark of aging and risk factor for cardiovascular disease, yet its regulation is poorly understood. Here we use mouse modeling to show that matrix metalloproteinase-12 (MMP12), a potent elastase, is essential for acute and chronic arterial stiffening. MMP12 was induced in...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Liu, Shu-Lin, Bae, Yong Ho, Yu, Christopher, Monslow, James, Hawthorne, Elizabeth A., Castagnino, Paola, Branchetti, Emanuela, Ferrari, Giovanni, Damrauer, Scott M., Puré, Ellen, Assoian, Richard K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660439/
https://ncbi.nlm.nih.gov/pubmed/26608672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17189
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