Cardiovascular protection by apoE and apoE-HDL linked to suppression of ECM gene expression and arterial stiffening

Arterial stiffening is a risk factor for cardiovascular disease, but how arteries stay supple is unknown. Here, we show that apolipoprotein E (apoE) and apoE-containing HDL maintain arterial elasticity by suppressing the expression of extracellular matrix genes. ApoE interrupts a mechanically driven...

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Detalhes bibliográficos
Main Authors: Kothapalli, Devashish, Liu, Shu-Lin, Bae, Yong Ho, Monslow, James, Xu, Tina, Hawthorne, Elizabeth A., Byfield, Fitzroy J., Castagnino, Paola, Rao, Shilpa, Rader, Daniel J., Puré, Ellen, Phillips, Michael C., Lund-Katz, Sissel, Janmey, Paul A., Assoian, Richard K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535179/
https://ncbi.nlm.nih.gov/pubmed/23103162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.09.018
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