Antimitogenic effects of HDL and APOE mediated by Cox-2–dependent IP activation

HDL and its associated apo, APOE, inhibit S-phase entry of murine aortic smooth muscle cells. We report here that the antimitogenic effect of APOE maps to the N-terminal receptor–binding domain, that APOE and its N-terminal domain inhibit activation of the cyclin A promoter, and that these effects i...

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Detalhes bibliográficos
Main Authors: Kothapalli, Devashish, Fuki, Ilia, Ali, Kamilah, Stewart, Sheryl A., Zhao, Liang, Yahil, Ron, Kwiatkowski, David, Hawthorne, Elizabeth A., FitzGerald, Garret A., Phillips, Michael C., Lund-Katz, Sissel, Puré, Ellen, Rader, Daniel J., Assoian, Richard K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC338263/
https://ncbi.nlm.nih.gov/pubmed/14966570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419097
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