Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy

The human TEAD family of transcription factors (TEAD1-4) is required for YAP-mediated transcription in the Hippo pathway. Hyperactivation of TEAD’s co-activator YAP contributes to tissue overgrowth and human cancers, suggesting that pharmacological interference of TEAD-YAP activity may be an effecti...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Pobbati, Ajaybabu V., Han, Xiao, Hung, Alvin W., Weiguang, Seetoh, Huda, Nur, Chen, Guo-Ying, Kang, CongBao, Chia, Cheng San Brian, Luo, Xuelian, Hong, Wanjin, Poulsen, Anders
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660270/
https://ncbi.nlm.nih.gov/pubmed/26592798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.09.009
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