Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket

[Image: see text] Transcriptional enhanced associate domain (TEAD) transcription factors together with coactivators and corepressors modulate the expression of genes that regulate fundamental processes, such as organogenesis and cell growth, and elevated TEAD activity is associated with tumorigenesi...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Karatas, Hacer, Akbarzadeh, Mohammad, Adihou, Hélène, Hahne, Gernot, Pobbati, Ajaybabu V., Yihui Ng, Elizabeth, Guéret, Stéphanie M., Sievers, Sonja, Pahl, Axel, Metz, Malte, Zinken, Sarah, Dötsch, Lara, Nowak, Christine, Thavam, Sasikala, Friese, Alexandra, Kang, CongBao, Hong, Wanjin, Waldmann, Herbert
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586386/
https://ncbi.nlm.nih.gov/pubmed/32907324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01275
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