ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS and FTD remain controversial. We propose a model in which low-complexity (LC) domains of FUS drive its physiologically reversible assembly into membrane-free, liquid droplet and hydrogel-like structures. ALS/FTD mutati...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Neuron
मुख्य लेखकों: Murakami, Tetsuro, Qamar, Seema, Lin, Julie Qiaojin, Schierle, Gabriele S. Kaminski, Rees, Eric, Miyashita, Akinori, Costa, Ana R., Dodd, Roger B., Chan, Fiona T.S., Michel, Claire H., Kronenberg-Versteeg, Deborah, Li, Yi, Yang, Seung-Pil, Wakutani, Yosuke, Meadows, William, Ferry, Rodylyn Rose, Dong, Liang, Tartaglia, Gian Gaetano, Favrin, Giorgio, Lin, Wen-Lang, Dickson, Dennis W., Zhen, Mei, Ron, David, Schmitt-Ulms, Gerold, Fraser, Paul E., Shneider, Neil A., Holt, Christine, Vendruscolo, Michele, Kaminski, Clemens F., St George-Hyslop, Peter
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Cell Press 2015
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660210/
https://ncbi.nlm.nih.gov/pubmed/26526393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.10.030
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