The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling

Antigen receptor signalling activates the canonical NF-κB pathway via the CARD11/BCL10/MALT1 (CBM) signalosome involving key, yet ill-defined roles for linear ubiquitination. The paracaspase MALT1 cleaves and removes negative checkpoint proteins, amplifying lymphocyte responses in NF-κB activation a...

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Publicat a:Nat Commun
Autors principals: Klein, Theo, Fung, Shan-Yu, Renner, Florian, Blank, Michael A., Dufour, Antoine, Kang, Sohyeong, Bolger-Munro, Madison, Scurll, Joshua M., Priatel, John J., Schweigler, Patrick, Melkko, Samu, Gold, Michael R., Viner, Rosa I., Régnier, Catherine H., Turvey, Stuart E., Overall, Christopher M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659944/
https://ncbi.nlm.nih.gov/pubmed/26525107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9777
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