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Masking MALT1: the paracaspase's potential for cancer therapy
A key feature of aggressive B cell lymphomas is constitutive NF-κB activation, which requires signals from the CARD11–BCL-10–MALT1 (CMB) complex. The unique enzymatic activity of MALT1 degrades one of its binding partners, BCL-10, as well as the NF-κB inhibitor A20. New data shows that targeting MAL...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768848/ https://ncbi.nlm.nih.gov/pubmed/19841088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092160 |
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