MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment

Inflammation promotes phenotypic plasticity in melanoma, a source of non-genetic heterogeneity, but the molecular framework is poorly understood. Here we use functional genomic approaches and identify a reciprocal antagonism between the melanocyte lineage transcription factor MITF and c-Jun, which i...

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Publicado no:Nat Commun
Main Authors: Riesenberg, Stefanie, Groetchen, Angela, Siddaway, Robert, Bald, Tobias, Reinhardt, Julia, Smorra, Denise, Kohlmeyer, Judith, Renn, Marcel, Phung, Bengt, Aymans, Pia, Schmidt, Tobias, Hornung, Veit, Davidson, Irwin, Goding, Colin R., Jönsson, Göran, Landsberg, Jennifer, Tüting, Thomas, Hölzel, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659938/
https://ncbi.nlm.nih.gov/pubmed/26530832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9755
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